UniProt

function

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

Catalytic activity

Rhea 10532

(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.

Features

Showing features for active site.

TypeIDPosition(s)DescriptionActive site49Proton acceptorActive site60Proton acceptor

Gene Ontology

Gene Ontology (GO) annotations organized by slimming set.

AspectTermMolecular Functionlyase activityMolecular Functionmolecular adaptor activityMolecular Functiontryptophan synthase activityBiological Processaromatic amino acid family biosynthetic processBiological ProcessL-tryptophan biosynthetic process

Access the complete set of GO annotations on QuickGO

Keywords

Molecular function

Biological process

Enzyme and pathway databases

UPA00035UER00044

Protein names

Recommended name

Tryptophan synthase alpha chain

Gene names

Name

trpA

Ordered locus names

b1260, JW1252

Organism names

Taxonomic identifier

Organism

Strains

K12 / W3110 / ATCC 27325 / DSM 5911K12 / MG1655 / ATCC 47076K12 / EMG2K12

Taxonomic lineage

Bacteria > Pseudomonadati > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

Primary accession

P0A877

Secondary accessions

P00928Q47669

Proteomes

Identifier

Component

Chromosome

Features

Showing features for natural variant.

TypeIDPosition(s)DescriptionNatural variant209-224in mutant TrpA46-Asp-PR3

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

Features

Showing features for chain.

TypeIDPosition(s)DescriptionChainPRO_00000987781-268Tryptophan synthase alpha chain

Proteomic databases

Sequence similarities

Belongs to the TrpA family.

Phylogenomic databases

COG0159Bacteria

Family and domain databases

cd04724Tryptophan_synthase_alpha 1 hit3.20.20.70:FF:000037Tryptophan synthase alpha chain 1 hit3.20.20.70Aldolase class I 1 hitMF_00131Trp_synth_alpha 1 hitView protein in InterProIPR013785Aldolase_TIMIPR011060RibuloseP-bd_barrelIPR018204Trp_synthase_alpha_ASIPR002028Trp_synthase_suATIGR00262trpA 1 hitPTHR43406:SF1TRYPTOPHAN SYNTHASE ALPHA CHAIN, CHLOROPLASTIC 1 hitPTHR43406TRYPTOPHAN SYNTHASE, ALPHA CHAIN 1 hitSSF51366Ribulose-phoshate binding barrel 1 hit

Sequence status

Complete

Length

268

Mass (Da)

28,724

Last updated

1986-07-21 v1

MD5 Checksum

1F1188D5FB1C600B0F1C9E3DD8F05EB8

MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS

Keywords

Technical term

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatusV00364
EMBL· GenBank· DDBJCAA23662.1
EMBL· GenBank· DDBJGenomic DNA V00372
EMBL· GenBank· DDBJCAA23675.1
EMBL· GenBank· DDBJGenomic DNA J01714
EMBL· GenBank· DDBJAAA57301.1
EMBL· GenBank· DDBJGenomic DNA U23489
EMBL· GenBank· DDBJAAB60035.1
EMBL· GenBank· DDBJGenomic DNA U23490
EMBL· GenBank· DDBJAAA65140.1
EMBL· GenBank· DDBJGenomic DNA U23491
EMBL· GenBank· DDBJAAA65146.1
EMBL· GenBank· DDBJGenomic DNA U23492
EMBL· GenBank· DDBJAAA65152.1
EMBL· GenBank· DDBJGenomic DNA U23494
EMBL· GenBank· DDBJAAA65164.1
EMBL· GenBank· DDBJGenomic DNA U25417
EMBL· GenBank· DDBJAAA73791.1
EMBL· GenBank· DDBJGenomic DNA U25418
EMBL· GenBank· DDBJAAA73797.1
EMBL· GenBank· DDBJGenomic DNA U25419
EMBL· GenBank· DDBJAAA73803.1
EMBL· GenBank· DDBJGenomic DNA U25420
EMBL· GenBank· DDBJAAA73809.1
EMBL· GenBank· DDBJGenomic DNA U25421
EMBL· GenBank· DDBJAAA73815.1
EMBL· GenBank· DDBJGenomic DNA U25422
EMBL· GenBank· DDBJAAA73821.1
EMBL· GenBank· DDBJGenomic DNA U00096
EMBL· GenBank· DDBJAAC74342.1
EMBL· GenBank· DDBJGenomic DNA AP009048
EMBL· GenBank· DDBJBAA14792.1
EMBL· GenBank· DDBJGenomic DNA X16698
EMBL· GenBank· DDBJCAA34671.1
EMBL· GenBank· DDBJGenomic DNA

Genome annotation databases

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.

网址：UniProt https://c.klqsh.com/news/view/106011

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