南方鲇（Silurus meridionalis）心脏、肝脏、肾脏、脑和白肌中线粒体经季节性驯化后的代谢补偿。

合理补充蛋白质，保证肝脏正常代谢需求。 #生活知识# #科技生活# #健康生活技巧# #脂肪肝#

Metabolic compensations in mitochondria isolated from the heart, liver, kidney, brain and white muscle in the southern catfish (Silurus meridionalis) by seasonal acclimation.

作者信息

Yan Yulian, Xie Xiaojun

机构信息

Institute of Hydrobiology and Water Environment, School of Life Sciences, Southwest University, Chongqing 400715, China.

出版信息

Comp Biochem Physiol A Mol Integr Physiol. 2015 May;183:64-71. doi: 10.1016/j.cbpa.2014.12.011. Epub 2014 Dec 11.

Abstract

In order to examine the effects of seasonal acclimation on mitochondrial metabolic functions and test tissue-specific pattern of the metabolic compensation within individuals of the southern catfish (Silurus meridionalis Chen), rates of mitochondrial respiration and activities of cytochrome c oxidase (COX) in the heart, liver, kidney, brain and white muscle of this fish in the summer-acclimatized group (153.20±1.66 g) and winter-acclimatized group (177.71±3.04 g) were measured at seven assay temperatures (7.5, 12.5, 17.5, 22.5, 27.5, 32.5 and 37.5°C), respectively. The results show that compensatory adjustments in state III respiratory rate and COX activity occur significantly in the heart, kidney and liver, but do not in the brain and white muscle, which suggest that the metabolic compensation of this fish in response to seasonal acclimation exhibits a tissue-specific pattern. The cold acclimation increases mitochondrial oxidative capacities in the heart, kidney and liver concomitantly with reducing their upper thermal limits of mitochondrial functions at acute warming and the thermal tolerance shifts in the same tissue-specific pattern as the metabolic compensation. When combining the effects of seasonal acclimation on mitochondrial oxidative capacity and organ mass, the metabolic compensation demonstrates an organ-specific pattern with four categories: over-compensation in the heart, complete compensation in the kidney, partial compensation in the liver and no compensation in the brain. The organ-specific pattern of metabolic compensation might be a trade-off strategy of the performance adjustments in the seasonal acclimation for this fish to maximize its fitness.

摘要

为了研究季节性驯化对线粒体代谢功能的影响，并测试南方鲇（Silurus meridionalis Chen）个体内代谢补偿的组织特异性模式，分别在七个测定温度（7.5、12.5、17.5、22.5、27.5、32.5和37.5°C）下，测定了夏季驯化组（153.20±1.66 g）和冬季驯化组（177.71±3.04 g）南方鲇心脏、肝脏、肾脏、脑和白色肌肉中线粒体呼吸速率以及细胞色素c氧化酶（COX）的活性。结果表明，心脏、肾脏和肝脏中状态III呼吸速率和COX活性出现显著的补偿性调整，而脑和白色肌肉中则没有，这表明该鱼对季节性驯化的代谢补偿呈现出组织特异性模式。冷驯化增加了心脏、肾脏和肝脏中线粒体的氧化能力，同时降低了它们在急性升温时线粒体功能的上限热限，并且热耐受性以与代谢补偿相同的组织特异性模式发生变化。当结合季节性驯化对线粒体氧化能力和器官质量的影响时，代谢补偿呈现出器官特异性模式，分为四类：心脏过度补偿、肾脏完全补偿、肝脏部分补偿、脑无补偿。代谢补偿的器官特异性模式可能是该鱼在季节性驯化中进行性能调整的一种权衡策略，以使其适应性最大化。

网址：南方鲇（Silurus meridionalis）心脏、肝脏、肾脏、脑和白肌中线粒体经季节性驯化后的代谢补偿。 https://c.klqsh.com/news/view/357270

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